Articles

COVER

• Confronting the Clinical Challenges of Frontotemporal Dementia

  A look at FTD’s symptoms, pathophysiology, subtypes, as well as the latest from imaging studies.

  By Zac Haughn, Senior Associate Editor

FEATURES

• Case Report: Leber Hereditary Optic Neuropathy in a 60-Year-Old Man with Vitamin B12 Deficiency

  LHON should be considered as a diagnosis in patients, regardless of age, with unexplained bilateral optic neuropathy and central vision loss.

  By Darby D. Miller, MD, Craig E. Geist, MD, and Charles J. Macri, MD

• Neurology Clinical Trials in the Community Hospital Setting

  A significant trend, encouraged by NIH, is expanding clinical research to community hospitals with potential benefits for patients and clinicians.

  By David M. Brown, MD, and Laura Whitaker, RN

DEPARTMENTS

• In The News: Products in MS Pipeline Move Forward

• Editor’s Message

  By Paul Winnington

• Dementia Insights: The Role of Cognitive Fluctuations and Impaired Episodic Memory in the Diagnosis of Dementia: New Considerations

  Studies suggest that the presence of cognitive fluctuations and abnormalities in episodic memory and delayed recall can occur in several dementias.

  By Ronald Devere, MD

• Expert Opinion: Neuropsychological Impairments In Females with Primary Sjögren’s Syndrome: New Insights

  The pSS literature has reported varying degrees of central nervous system involvement in individuals with this condition and secondary cognitive deficits associated with the disease.

  By Tiffany Jennings, PsyD; Frederick Vivino, MD; Steven Mandel, MD; Kenneth Goldberg, PsyD; Edward Maitz, PhD; Bret Boyer, PhD